Centlein (CNTLN)
Homo sapiens — UniProt Q9NXG0
Data last refreshed: (UniProt release unknown)
Key facts
Centlein (CNTLN) is a protein from Homo sapiens identified by UniProt accession Q9NXG0, 1405 residues long. MolForge cross-references it against 0 known binders and 147 disease associations.
- UniProt accession: Q9NXG0; gene symbol CNTLN.
- Organism: Homo sapiens.
- Length: 1405 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist-hip ratio, unipolar depression and BMI-adjusted waist circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centlein |
|---|---|
| UniProt accession | Q9NXG0 |
| Gene | CNTLN |
| Organism | Homo sapiens |
| Length | 1405 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (147)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.38
- unipolar depression · score 0.35
- BMI-adjusted waist circumference · score 0.33
- waist-hip ratio · score 0.32
- high density lipoprotein cholesterol measurement · score 0.25
- cortical surface area measurement · score 0.24
- body height · score 0.23
- vital capacity · score 0.23
- age-related hearing impairment · score 0.22
- adolescent idiopathic scoliosis · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXG0-F1 | alphafold | PREDICTED | 70.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXG0.
Amino-acid sequence (1405 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CNTLN?
The strongest Open Targets associations for CNTLN are BMI-adjusted waist-hip ratio, unipolar depression, BMI-adjusted waist circumference, waist-hip ratio and high density lipoprotein cholesterol measurement.
How long is the CNTLN protein?
The Homo sapiens CNTLN protein (UniProt Q9NXG0) is 1405 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXG0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXG0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.