Transmembrane prolyl 4-hydroxylase (P4HTM)
Homo sapiens — UniProt Q9NXG6
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane prolyl 4-hydroxylase (P4HTM) is a protein from Homo sapiens identified by UniProt accession Q9NXG6, 502 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.
- UniProt accession: Q9NXG6; gene symbol P4HTM.
- Organism: Homo sapiens.
- Length: 502 amino acids.
- Top disease associations (Open Targets): hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities, anemia (phenotype) and chronic kidney disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane prolyl 4-hydroxylase |
|---|---|
| UniProt accession | Q9NXG6 |
| Gene | P4HTM |
| Organism | Homo sapiens |
| Length | 502 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (134)
Diseases linked to this target (Open Targets).
- hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities · score 0.69
- anemia (phenotype) · score 0.58
- chronic kidney disease · score 0.56
- Intellectual disability · score 0.54
- Global developmental delay · score 0.46
- Seizure · score 0.46
- Hypotonia · score 0.46
- myelodysplastic syndrome · score 0.40
- sleep apnea · score 0.37
- Abnormality of the eye · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXG6-F1 | alphafold | PREDICTED | 81.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXG6.
Amino-acid sequence (502 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with P4HTM?
The strongest Open Targets associations for P4HTM are hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities, anemia (phenotype), chronic kidney disease, Intellectual disability and Global developmental delay.
How long is the P4HTM protein?
The Homo sapiens P4HTM protein (UniProt Q9NXG6) is 502 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXG6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXG6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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