Protein phosphatase 1 regulatory subunit 14D (PPP1R14D)
Homo sapiens — UniProt Q9NXH3
Data last refreshed: (UniProt release unknown)
Key facts
Protein phosphatase 1 regulatory subunit 14D (PPP1R14D) is a protein from Homo sapiens identified by UniProt accession Q9NXH3, 145 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q9NXH3; gene symbol PPP1R14D.
- Organism: Homo sapiens.
- Length: 145 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, Barrett's esophagus and Blackfan-Diamond anemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein phosphatase 1 regulatory subunit 14D |
|---|---|
| UniProt accession | Q9NXH3 |
| Gene | PPP1R14D |
| Organism | Homo sapiens |
| Length | 145 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.09
- Barrett's esophagus · score 0.06
- Blackfan-Diamond anemia · score 0.06
- non-small cell lung carcinoma · score 0.05
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.05
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.05
- hemoglobin D disease · score 0.04
- Heinz body anemia · score 0.04
- delta-beta-thalassemia · score 0.04
- IRIDA syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXH3-F1 | alphafold | PREDICTED | 73.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXH3.
Amino-acid sequence (145 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPP1R14D?
The strongest Open Targets associations for PPP1R14D are lung adenocarcinoma, Barrett's esophagus, Blackfan-Diamond anemia, non-small cell lung carcinoma and Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16.
How long is the PPP1R14D protein?
The Homo sapiens PPP1R14D protein (UniProt Q9NXH3) is 145 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXH3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXH3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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