Torsin-4A (TOR4A)
Homo sapiens — UniProt Q9NXH8
Data last refreshed: (UniProt release unknown)
Key facts
Torsin-4A (TOR4A) is a protein from Homo sapiens identified by UniProt accession Q9NXH8, 423 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q9NXH8; gene symbol TOR4A.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, ulcerative colitis and chronotype measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Torsin-4A |
|---|---|
| UniProt accession | Q9NXH8 |
| Gene | TOR4A |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- ulcerative colitis · score 0.05
- chronotype measurement · score 0.05
- osteosarcoma · score 0.03
- mathematical ability · score 0.03
- brain volume measurement · score 0.03
- tiredness measurement · score 0.03
- insomnia measurement · score 0.03
- multisite chronic pain · score 0.03
- self reported educational attainment · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXH8-F1 | alphafold | PREDICTED | 79.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXH8.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TOR4A?
The strongest Open Targets associations for TOR4A are neurodegenerative disease, ulcerative colitis, chronotype measurement, osteosarcoma and mathematical ability.
How long is the TOR4A protein?
The Homo sapiens TOR4A protein (UniProt Q9NXH8) is 423 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXH8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXH8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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