tRNA (guanine(26)-N(2))-dimethyltransferase (TRMT1)
Homo sapiens — UniProt Q9NXH9
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (guanine(26)-N(2))-dimethyltransferase (TRMT1) is a protein from Homo sapiens identified by UniProt accession Q9NXH9, 659 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9NXH9; gene symbol TRMT1.
- Organism: Homo sapiens.
- Length: 659 amino acids.
- Top disease associations (Open Targets): autosomal recessive non-syndromic intellectual disability, genetic disorder and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (guanine(26)-N(2))-dimethyltransferase |
|---|---|
| UniProt accession | Q9NXH9 |
| Gene | TRMT1 |
| Organism | Homo sapiens |
| Length | 659 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- autosomal recessive non-syndromic intellectual disability · score 0.55
- genetic disorder · score 0.47
- Intellectual disability · score 0.37
- Global developmental delay · score 0.37
- complex neurodevelopmental disorder · score 0.37
- mean platelet volume · score 0.27
- platelet count · score 0.22
- Red cell distribution width · score 0.22
- creatinine measurement · score 0.21
- serum urea measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXH9-F1 | alphafold | PREDICTED | 81.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXH9.
Amino-acid sequence (659 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRMT1?
The strongest Open Targets associations for TRMT1 are autosomal recessive non-syndromic intellectual disability, genetic disorder, Intellectual disability, Global developmental delay and complex neurodevelopmental disorder.
How long is the TRMT1 protein?
The Homo sapiens TRMT1 protein (UniProt Q9NXH9) is 659 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXH9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXH9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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