E3 ubiquitin-protein ligase RNF186 (RNF186)
Homo sapiens — UniProt Q9NXI6
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF186 (RNF186) is a protein from Homo sapiens identified by UniProt accession Q9NXI6, 227 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9NXI6; gene symbol RNF186.
- Organism: Homo sapiens.
- Length: 227 amino acids.
- Top disease associations (Open Targets): creatinine measurement, ulcerative colitis and inflammatory bowel disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF186 |
|---|---|
| UniProt accession | Q9NXI6 |
| Gene | RNF186 |
| Organism | Homo sapiens |
| Length | 227 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.52
- ulcerative colitis · score 0.37
- inflammatory bowel disease · score 0.34
- neurodegenerative disease · score 0.31
- urate measurement · score 0.29
- Crohn's disease · score 0.27
- rheumatoid arthritis · score 0.21
- ankylosing spondylitis · score 0.21
- sclerosing cholangitis · score 0.21
- psoriasis · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXI6-F1 | alphafold | PREDICTED | 68.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXI6.
Amino-acid sequence (227 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF186?
The strongest Open Targets associations for RNF186 are creatinine measurement, ulcerative colitis, inflammatory bowel disease, neurodegenerative disease and urate measurement.
How long is the RNF186 protein?
The Homo sapiens RNF186 protein (UniProt Q9NXI6) is 227 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXI6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXI6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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