Membrane-spanning 4-domains subfamily A member 12 (MS4A12)
Homo sapiens — UniProt Q9NXJ0
Data last refreshed: (UniProt release unknown)
Key facts
Membrane-spanning 4-domains subfamily A member 12 (MS4A12) is a protein from Homo sapiens identified by UniProt accession Q9NXJ0, 267 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9NXJ0; gene symbol MS4A12.
- Organism: Homo sapiens.
- Length: 267 amino acids.
- Top disease associations (Open Targets): lymphocyte count, blood protein measurement and neutrophil percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Membrane-spanning 4-domains subfamily A member 12 |
|---|---|
| UniProt accession | Q9NXJ0 |
| Gene | MS4A12 |
| Organism | Homo sapiens |
| Length | 267 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.29
- blood protein measurement · score 0.29
- neutrophil percentage of leukocytes · score 0.07
- colorectal cancer · score 0.05
- colorectal adenocarcinoma · score 0.04
- Crohn's disease · score 0.04
- carcinoma · score 0.03
- immunodeficiency 75 · score 0.03
- Kimura disease · score 0.03
- Hepatic veno-occlusive disease - immunodeficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXJ0-F1 | alphafold | PREDICTED | 71.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXJ0.
Amino-acid sequence (267 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MS4A12?
The strongest Open Targets associations for MS4A12 are lymphocyte count, blood protein measurement, neutrophil percentage of leukocytes, colorectal cancer and colorectal adenocarcinoma.
How long is the MS4A12 protein?
The Homo sapiens MS4A12 protein (UniProt Q9NXJ0) is 267 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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