Pyroglutamyl-peptidase 1 (PGPEP1)
Homo sapiens — UniProt Q9NXJ5
Data last refreshed: (UniProt release unknown)
Key facts
Pyroglutamyl-peptidase 1 (PGPEP1) is a protein from Homo sapiens identified by UniProt accession Q9NXJ5, 209 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.
- UniProt accession: Q9NXJ5; gene symbol PGPEP1.
- Organism: Homo sapiens.
- Length: 209 amino acids.
- Top disease associations (Open Targets): body mass index, body fat percentage and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pyroglutamyl-peptidase 1 |
|---|---|
| UniProt accession | Q9NXJ5 |
| Gene | PGPEP1 |
| Organism | Homo sapiens |
| Length | 209 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (65)
Diseases linked to this target (Open Targets).
- body mass index · score 0.35
- body fat percentage · score 0.32
- systolic blood pressure · score 0.31
- fat body mass · score 0.30
- smoking status measurement · score 0.27
- cortical surface area measurement · score 0.26
- Beta blocking agent use measurement · score 0.26
- chronotype measurement · score 0.26
- lean body mass · score 0.25
- hypertension · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXJ5-F1 | alphafold | PREDICTED | 93.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXJ5.
Amino-acid sequence (209 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PGPEP1?
The strongest Open Targets associations for PGPEP1 are body mass index, body fat percentage, systolic blood pressure, fat body mass and smoking status measurement.
How long is the PGPEP1 protein?
The Homo sapiens PGPEP1 protein (UniProt Q9NXJ5) is 209 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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