F-box/LRR-repeat protein 12 (FBXL12)
Homo sapiens — UniProt Q9NXK8
Data last refreshed: (UniProt release unknown)
Key facts
F-box/LRR-repeat protein 12 (FBXL12) is a protein from Homo sapiens identified by UniProt accession Q9NXK8, 326 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.
- UniProt accession: Q9NXK8; gene symbol FBXL12.
- Organism: Homo sapiens.
- Length: 326 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body height and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/LRR-repeat protein 12 |
|---|---|
| UniProt accession | Q9NXK8 |
| Gene | FBXL12 |
| Organism | Homo sapiens |
| Length | 326 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (7)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- body height · score 0.25
- heel bone mineral density · score 0.12
- sleep duration · score 0.02
- appendicular lean mass · score 0.02
- cancer · score 0.02
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXK8-F1 | alphafold | PREDICTED | 89.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXK8.
Amino-acid sequence (326 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXL12?
The strongest Open Targets associations for FBXL12 are neurodegenerative disease, body height, heel bone mineral density, sleep duration and appendicular lean mass.
How long is the FBXL12 protein?
The Homo sapiens FBXL12 protein (UniProt Q9NXK8) is 326 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXK8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXK8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.