Rho guanine nucleotide exchange factor 38 (ARHGEF38)
Homo sapiens — UniProt Q9NXL2
Data last refreshed: (UniProt release unknown)
Key facts
Rho guanine nucleotide exchange factor 38 (ARHGEF38) is a protein from Homo sapiens identified by UniProt accession Q9NXL2, 777 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q9NXL2; gene symbol ARHGEF38.
- Organism: Homo sapiens.
- Length: 777 amino acids.
- Top disease associations (Open Targets): FEV/FVC ratio, chronic obstructive pulmonary disease and neurofibrillary tangles measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 38 |
|---|---|
| UniProt accession | Q9NXL2 |
| Gene | ARHGEF38 |
| Organism | Homo sapiens |
| Length | 777 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.33
- chronic obstructive pulmonary disease · score 0.33
- neurofibrillary tangles measurement · score 0.25
- PHF-tau measurement · score 0.25
- breast adenocarcinoma · score 0.18
- sitting height measurement · score 0.12
- mean reticulocyte volume · score 0.06
- hypertriglyceridemia 2 · score 0.06
- body weight · score 0.06
- vital capacity · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXL2-F1 | alphafold | PREDICTED | 74.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXL2.
Amino-acid sequence (777 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGEF38?
The strongest Open Targets associations for ARHGEF38 are FEV/FVC ratio, chronic obstructive pulmonary disease, neurofibrillary tangles measurement, PHF-tau measurement and breast adenocarcinoma.
How long is the ARHGEF38 protein?
The Homo sapiens ARHGEF38 protein (UniProt Q9NXL2) is 777 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXL2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXL2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.