Ganglioside-induced differentiation-associated protein 2 (GDAP2)
Homo sapiens — UniProt Q9NXN4
Data last refreshed: (UniProt release unknown)
Key facts
Ganglioside-induced differentiation-associated protein 2 (GDAP2) is a protein from Homo sapiens identified by UniProt accession Q9NXN4, 497 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q9NXN4; gene symbol GDAP2.
- Organism: Homo sapiens.
- Length: 497 amino acids.
- Top disease associations (Open Targets): spinocerebellar ataxia, autosomal recessive, 27, Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ganglioside-induced differentiation-associated protein 2 |
|---|---|
| UniProt accession | Q9NXN4 |
| Gene | GDAP2 |
| Organism | Homo sapiens |
| Length | 497 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia, autosomal recessive, 27 · score 0.57
- Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome · score 0.18
- reticulocyte count · score 0.18
- myeloid white cell count · score 0.05
- age-related hearing impairment · score 0.05
- mean corpuscular hemoglobin concentration · score 0.04
- mean corpuscular volume · score 0.04
- Red cell distribution width · score 0.03
- mean corpuscular hemoglobin · score 0.03
- body height · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXN4-F1 | alphafold | PREDICTED | 82.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXN4.
Amino-acid sequence (497 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GDAP2?
The strongest Open Targets associations for GDAP2 are spinocerebellar ataxia, autosomal recessive, 27, Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome, reticulocyte count, myeloid white cell count and age-related hearing impairment.
How long is the GDAP2 protein?
The Homo sapiens GDAP2 protein (UniProt Q9NXN4) is 497 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXN4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXN4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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