Gypsy retrotransposon integrase-like protein 1 (GIN1)

About Gypsy retrotransposon integrase-like protein 1

Gypsy retrotransposon integrase-like protein 1 (GIN1) is a protein from Homo sapiens identified by UniProt accession Q9NXP7, 522 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	Gypsy retrotransposon integrase-like protein 1
UniProt accession	Q9NXP7
Gene	GIN1
Organism	Homo sapiens
Length	522 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.37
BMI-adjusted waist-hip ratio · score 0.36
sleep duration · score 0.33
type 2 diabetes mellitus · score 0.27
body height · score 0.24
mean corpuscular volume · score 0.24
insomnia measurement · score 0.22
Parkinson disease · score 0.22
diabetes mellitus · score 0.22
mathematical ability · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9NXP7-F1	alphafold	PREDICTED	70.34	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXP7.

Amino-acid sequence (522 residues)

MVRSGKNGDL HLKQIAYYKR TGEYHSTTLP SERSGIRRAA KKFVFKEKKL FYVGKDRKQN RLVIVSEEEK KKVLRECHEN DSGAHHGISR TLTLVESNYY WTSVTNDVKQ WVYACQHCQV AKNTVIVAPK QHLLKVENPW SLVTVDLMGP FHTSNRSHVY AIIMTDLFTK WIVILPLCDV SASEVSKAII NIFFLYGPPQ KIIMDQRDEF IQQINIELYR LFGIKQIVIS HTSGTVNPTE STPNTIKAFL SKHCADHPNN WDDHLSAVSF AFNVTHLEPT KNTPYFQMFS RNPYMPETSD SLHEVDGDNT SMFAKILDAI KEADKIMENK TTSLGQMENN NLDELNKSKI IVKKKPKQLN PFHLKVGHEV LRQRKNWWKD GRFQSEWVGP CVIDYITESG CAVLRDNTGV RLKRPIKMSH LKPYIRESSE QESLYLLQGS VVADHDYIGL PEIPIGAYQA NILVEDATIG IVDNELLTSS KDRELLEYRN TKISPLIDDH SSLEKQTFSL LDSSNQVLEY LS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards