Nuclear distribution protein nudE homolog 1 (NDE1)
Homo sapiens — UniProt Q9NXR1
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear distribution protein nudE homolog 1 (NDE1) is a protein from Homo sapiens identified by UniProt accession Q9NXR1, 335 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q9NXR1; gene symbol NDE1.
- Organism: Homo sapiens.
- Length: 335 amino acids.
- Top disease associations (Open Targets): lissencephaly 4, NDE1-related microhydranencephaly and familial thoracic aortic aneurysm and aortic dissection.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear distribution protein nudE homolog 1 |
|---|---|
| UniProt accession | Q9NXR1 |
| Gene | NDE1 |
| Organism | Homo sapiens |
| Length | 335 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- lissencephaly 4 · score 0.76
- NDE1-related microhydranencephaly · score 0.61
- familial thoracic aortic aneurysm and aortic dissection · score 0.55
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.50
- megacystis-microcolon-intestinal hypoperistalsis syndrome 2 · score 0.46
- familial visceral myopathy · score 0.46
- aortic aneurysm · score 0.38
- marfan syndrome/loeys-dietz syndrome/familial thoracic aortic aneurysms and dissections · score 0.37
- autosomal recessive primary microcephaly · score 0.37
- Primary microcephaly · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXR1-F1 | alphafold | PREDICTED | 76.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXR1.
Amino-acid sequence (335 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NDE1?
The strongest Open Targets associations for NDE1 are lissencephaly 4, NDE1-related microhydranencephaly, familial thoracic aortic aneurysm and aortic dissection, Rare disease with thoracic aortic aneurysm and aortic dissection and megacystis-microcolon-intestinal hypoperistalsis syndrome 2.
How long is the NDE1 protein?
The Homo sapiens NDE1 protein (UniProt Q9NXR1) is 335 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXR1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXR1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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