Inhibitor of growth protein 3 (ING3)
Homo sapiens — UniProt Q9NXR8
Data last refreshed: (UniProt release unknown)
Key facts
Inhibitor of growth protein 3 (ING3) is a protein from Homo sapiens identified by UniProt accession Q9NXR8, 418 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q9NXR8; gene symbol ING3.
- Organism: Homo sapiens.
- Length: 418 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alzheimer disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inhibitor of growth protein 3 |
|---|---|
| UniProt accession | Q9NXR8 |
| Gene | ING3 |
| Organism | Homo sapiens |
| Length | 418 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- Alzheimer disease · score 0.40
- lysosomal storage disease · score 0.40
- Parkinson disease · score 0.40
- multiple sclerosis · score 0.40
- head and neck squamous cell carcinoma · score 0.38
- protein measurement · score 0.32
- pachyonychia congenita · score 0.07
- Mobius syndrome · score 0.05
- cancer · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXR8-F1 | alphafold | PREDICTED | 64.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXR8.
Amino-acid sequence (418 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ING3?
The strongest Open Targets associations for ING3 are neurodegenerative disease, Alzheimer disease, lysosomal storage disease, Parkinson disease and multiple sclerosis.
How long is the ING3 protein?
The Homo sapiens ING3 protein (UniProt Q9NXR8) is 418 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXR8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXR8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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