Kelch-like protein 28 (KLHL28)
Homo sapiens — UniProt Q9NXS3
Data last refreshed: (UniProt release unknown)
Key facts
Kelch-like protein 28 (KLHL28) is a protein from Homo sapiens identified by UniProt accession Q9NXS3, 571 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q9NXS3; gene symbol KLHL28.
- Organism: Homo sapiens.
- Length: 571 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, Joubert syndrome 37 and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch-like protein 28 |
|---|---|
| UniProt accession | Q9NXS3 |
| Gene | KLHL28 |
| Organism | Homo sapiens |
| Length | 571 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.51
- Joubert syndrome 37 · score 0.50
- body height · score 0.30
- nicotine dependence symptom count · score 0.29
- sphingomyelin measurement · score 0.21
- metabolite measurement · score 0.08
- self reported educational attainment · score 0.04
- pyelonephritis · score 0.04
- systemic juvenile idiopathic arthritis · score 0.01
- myocardial infarction · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXS3-F1 | alphafold | PREDICTED | 92.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXS3.
Amino-acid sequence (571 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHL28?
The strongest Open Targets associations for KLHL28 are Joubert syndrome, Joubert syndrome 37, body height, nicotine dependence symptom count and sphingomyelin measurement.
How long is the KLHL28 protein?
The Homo sapiens KLHL28 protein (UniProt Q9NXS3) is 571 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXS3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXS3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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