BTB/POZ domain-containing protein KCTD5 (KCTD5)
Homo sapiens — UniProt Q9NXV2
Data last refreshed: (UniProt release unknown)
Key facts
BTB/POZ domain-containing protein KCTD5 (KCTD5) is a protein from Homo sapiens identified by UniProt accession Q9NXV2, 234 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9NXV2; gene symbol KCTD5.
- Organism: Homo sapiens.
- Length: 234 amino acids.
- Top disease associations (Open Targets): aspartate aminotransferase measurement, neurofibrillary tangles measurement and intraocular pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BTB/POZ domain-containing protein KCTD5 |
|---|---|
| UniProt accession | Q9NXV2 |
| Gene | KCTD5 |
| Organism | Homo sapiens |
| Length | 234 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.18
- neurofibrillary tangles measurement · score 0.16
- intraocular pressure measurement · score 0.14
- body fat percentage · score 0.10
- neoplasm · score 0.08
- cancer · score 0.08
- triple-negative breast cancer · score 0.07
- hypoparathyroidism, familial isolated, 2 · score 0.06
- Primary hypomagnesemia with secondary hypocalcemia · score 0.06
- pseudohypoparathyroidism type 2 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXV2-F1 | alphafold | PREDICTED | 77.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXV2.
Amino-acid sequence (234 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCTD5?
The strongest Open Targets associations for KCTD5 are aspartate aminotransferase measurement, neurofibrillary tangles measurement, intraocular pressure measurement, body fat percentage and neoplasm.
How long is the KCTD5 protein?
The Homo sapiens KCTD5 protein (UniProt Q9NXV2) is 234 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXV2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXV2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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