DnaJ homolog subfamily B member 12 (DNAJB12)
Homo sapiens — UniProt Q9NXW2
Data last refreshed: (UniProt release unknown)
Key facts
DnaJ homolog subfamily B member 12 (DNAJB12) is a protein from Homo sapiens identified by UniProt accession Q9NXW2, 375 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9NXW2; gene symbol DNAJB12.
- Organism: Homo sapiens.
- Length: 375 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, Abnormality of refraction and hair color.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DnaJ homolog subfamily B member 12 |
|---|---|
| UniProt accession | Q9NXW2 |
| Gene | DNAJB12 |
| Organism | Homo sapiens |
| Length | 375 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.20
- Abnormality of refraction · score 0.18
- hair color · score 0.16
- hair colour measurement · score 0.13
- age at menarche · score 0.12
- cognitive function measurement · score 0.11
- age at onset · score 0.10
- Myopia · score 0.10
- refractive error · score 0.10
- self reported educational attainment · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXW2-F1 | alphafold | PREDICTED | 76.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXW2.
Amino-acid sequence (375 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAJB12?
The strongest Open Targets associations for DNAJB12 are sex hormone-binding globulin measurement, Abnormality of refraction, hair color, hair colour measurement and age at menarche.
How long is the DNAJB12 protein?
The Homo sapiens DNAJB12 protein (UniProt Q9NXW2) is 375 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXW2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXW2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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