Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4)
Homo sapiens — UniProt Q9NXW9
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4) is a protein from Homo sapiens identified by UniProt accession Q9NXW9, 302 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9NXW9; gene symbol ALKBH4.
- Organism: Homo sapiens.
- Length: 302 amino acids.
- Top disease associations (Open Targets): mean platelet volume, non-small cell lung carcinoma and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 |
|---|---|
| UniProt accession | Q9NXW9 |
| Gene | ALKBH4 |
| Organism | Homo sapiens |
| Length | 302 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.09
- non-small cell lung carcinoma · score 0.08
- neoplasm · score 0.07
- appendicular lean mass · score 0.06
- cancer · score 0.03
- hepatocellular carcinoma · score 0.03
- diabetes mellitus · score 0.03
- type 2 diabetes mellitus · score 0.03
- chronotype measurement · score 0.03
- lung adenocarcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXW9-F1 | alphafold | PREDICTED | 89.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXW9.
Amino-acid sequence (302 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALKBH4?
The strongest Open Targets associations for ALKBH4 are mean platelet volume, non-small cell lung carcinoma, neoplasm, appendicular lean mass and cancer.
How long is the ALKBH4 protein?
The Homo sapiens ALKBH4 protein (UniProt Q9NXW9) is 302 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXW9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXW9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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