Non-structural maintenance of chromosomes element 4 homolog A (NSMCE4A)
Homo sapiens — UniProt Q9NXX6
Data last refreshed: (UniProt release unknown)
Key facts
Non-structural maintenance of chromosomes element 4 homolog A (NSMCE4A) is a protein from Homo sapiens identified by UniProt accession Q9NXX6, 385 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q9NXX6; gene symbol NSMCE4A.
- Organism: Homo sapiens.
- Length: 385 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Non-structural maintenance of chromosomes element 4 homolog A |
|---|---|
| UniProt accession | Q9NXX6 |
| Gene | NSMCE4A |
| Organism | Homo sapiens |
| Length | 385 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- breast adenocarcinoma · score 0.23
- heel bone mineral density · score 0.13
- bone quantitative ultrasound measurement · score 0.12
- bone density · score 0.09
- chronotype measurement · score 0.04
- Palmar Fibromatosis · score 0.04
- blood protein measurement · score 0.04
- diet measurement · score 0.04
- PHF-tau measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXX6-F1 | alphafold | PREDICTED | 69.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXX6.
Amino-acid sequence (385 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NSMCE4A?
The strongest Open Targets associations for NSMCE4A are neurodegenerative disease, breast adenocarcinoma, heel bone mineral density, bone quantitative ultrasound measurement and bone density.
How long is the NSMCE4A protein?
The Homo sapiens NSMCE4A protein (UniProt Q9NXX6) is 385 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXX6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXX6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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