Sarcoma antigen 1 (SAGE1)
Homo sapiens — UniProt Q9NXZ1
Data last refreshed: (UniProt release unknown)
Key facts
Sarcoma antigen 1 (SAGE1) is a protein from Homo sapiens identified by UniProt accession Q9NXZ1, 904 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9NXZ1; gene symbol SAGE1.
- Organism: Homo sapiens.
- Length: 904 amino acids.
- Top disease associations (Open Targets): hypertriglyceridemia 2, cholesterol-ester transfer protein deficiency and thyroid hormone metabolism, abnormal, 2.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sarcoma antigen 1 |
|---|---|
| UniProt accession | Q9NXZ1 |
| Gene | SAGE1 |
| Organism | Homo sapiens |
| Length | 904 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- hypertriglyceridemia 2 · score 0.08
- cholesterol-ester transfer protein deficiency · score 0.08
- thyroid hormone metabolism, abnormal, 2 · score 0.07
- sitosterolemia · score 0.07
- Combined hyperlipidemia · score 0.06
- homozygous familial hypercholesterolemia · score 0.06
- hypercholesterolemia, autosomal dominant, 3 · score 0.05
- hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.05
- hypercholesterolemia, autosomal dominant, type B · score 0.05
- pancreatic triacylglycerol lipase deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NXZ1-F1 | alphafold | PREDICTED | 50.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NXZ1.
Amino-acid sequence (904 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAGE1?
The strongest Open Targets associations for SAGE1 are hypertriglyceridemia 2, cholesterol-ester transfer protein deficiency, thyroid hormone metabolism, abnormal, 2, sitosterolemia and Combined hyperlipidemia.
How long is the SAGE1 protein?
The Homo sapiens SAGE1 protein (UniProt Q9NXZ1) is 904 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NXZ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NXZ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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