H/ACA ribonucleoprotein complex subunit 1 (GAR1)
Homo sapiens — UniProt Q9NY12
Data last refreshed: (UniProt release unknown)
Key facts
H/ACA ribonucleoprotein complex subunit 1 (GAR1) is a protein from Homo sapiens identified by UniProt accession Q9NY12, 217 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q9NY12; gene symbol GAR1.
- Organism: Homo sapiens.
- Length: 217 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, endometrial cancer and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | H/ACA ribonucleoprotein complex subunit 1 |
|---|---|
| UniProt accession | Q9NY12 |
| Gene | GAR1 |
| Organism | Homo sapiens |
| Length | 217 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- endometrial cancer · score 0.10
- lean body mass · score 0.07
- fat body mass · score 0.06
- whole body water mass · score 0.04
- body weight · score 0.04
- base metabolic rate measurement · score 0.04
- DNA methylation · score 0.04
- body height · score 0.03
- testosterone measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NY12-F1 | alphafold | PREDICTED | 63.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NY12.
Amino-acid sequence (217 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GAR1?
The strongest Open Targets associations for GAR1 are neurodegenerative disease, endometrial cancer, lean body mass, fat body mass and whole body water mass.
How long is the GAR1 protein?
The Homo sapiens GAR1 protein (UniProt Q9NY12) is 217 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NY12 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NY12 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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