Dipeptidyl peptidase 3 (DPP3)
Homo sapiens — UniProt Q9NY33
Data last refreshed: (UniProt release unknown)
Key facts
Dipeptidyl peptidase 3 (DPP3) is a protein from Homo sapiens identified by UniProt accession Q9NY33, 737 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.
- UniProt accession: Q9NY33; gene symbol DPP3.
- Organism: Homo sapiens.
- Length: 737 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, Bardet-Biedl syndrome and apolipoprotein B measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dipeptidyl peptidase 3 |
|---|---|
| UniProt accession | Q9NY33 |
| Gene | DPP3 |
| Organism | Homo sapiens |
| Length | 737 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (93)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.28
- Bardet-Biedl syndrome · score 0.26
- apolipoprotein B measurement · score 0.23
- erythrocyte count · score 0.21
- total cholesterol measurement · score 0.19
- mean corpuscular hemoglobin · score 0.17
- hematocrit · score 0.13
- neoplasm · score 0.09
- breast cancer · score 0.08
- esophageal squamous cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NY33-F1 | alphafold | PREDICTED | 95.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NY33.
Amino-acid sequence (737 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPP3?
The strongest Open Targets associations for DPP3 are low density lipoprotein cholesterol measurement, Bardet-Biedl syndrome, apolipoprotein B measurement, erythrocyte count and total cholesterol measurement.
How long is the DPP3 protein?
The Homo sapiens DPP3 protein (UniProt Q9NY33) is 737 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NY33 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NY33 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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