Bile acid-sensitive ion channel (ASIC5)
Homo sapiens — UniProt Q9NY37
Data last refreshed: (UniProt release unknown)
Key facts
Bile acid-sensitive ion channel (ASIC5) is a protein from Homo sapiens identified by UniProt accession Q9NY37, 505 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q9NY37; gene symbol ASIC5.
- Organism: Homo sapiens.
- Length: 505 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): habitual abortion, glioblastoma multiforme and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bile acid-sensitive ion channel |
|---|---|
| UniProt accession | Q9NY37 |
| Gene | ASIC5 |
| Organism | Homo sapiens |
| Length | 505 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- habitual abortion · score 0.33
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.12
- blood metabolite measurement · score 0.09
- myeloid white cell count · score 0.07
- serum gamma-glutamyl transferase measurement · score 0.07
- systolic blood pressure · score 0.06
- speech perception · score 0.06
- alcohol consumption measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NY37-F1 | alphafold | PREDICTED | 84.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NY37.
Amino-acid sequence (505 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ASIC5?
The strongest Open Targets associations for ASIC5 are habitual abortion, glioblastoma multiforme, breast adenocarcinoma, head and neck squamous cell carcinoma and blood metabolite measurement.
How long is the ASIC5 protein?
The Homo sapiens ASIC5 protein (UniProt Q9NY37) is 505 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NY37 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NY37 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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