BarH-like 2 homeobox protein (BARHL2)
Homo sapiens — UniProt Q9NY43
Data last refreshed: (UniProt release unknown)
Key facts
BarH-like 2 homeobox protein (BARHL2) is a protein from Homo sapiens identified by UniProt accession Q9NY43, 387 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q9NY43; gene symbol BARHL2.
- Organism: Homo sapiens.
- Length: 387 amino acids.
- Top disease associations (Open Targets): self reported educational attainment, chronotype measurement and age at first sexual intercourse measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BarH-like 2 homeobox protein |
|---|---|
| UniProt accession | Q9NY43 |
| Gene | BARHL2 |
| Organism | Homo sapiens |
| Length | 387 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.45
- chronotype measurement · score 0.43
- age at first sexual intercourse measurement · score 0.42
- mathematical ability · score 0.42
- smoking initiation · score 0.41
- body mass index · score 0.40
- smoking status measurement · score 0.40
- risk-taking behaviour · score 0.39
- intelligence · score 0.39
- alcohol consumption measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NY43-F1 | alphafold | PREDICTED | 61.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NY43.
Amino-acid sequence (387 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BARHL2?
The strongest Open Targets associations for BARHL2 are self reported educational attainment, chronotype measurement, age at first sexual intercourse measurement, mathematical ability and smoking initiation.
How long is the BARHL2 protein?
The Homo sapiens BARHL2 protein (UniProt Q9NY43) is 387 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NY43 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NY43 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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