Sphingomyelin phosphodiesterase 3 (SMPD3)
Homo sapiens — UniProt Q9NY59
Data last refreshed: (UniProt release unknown)
Key facts
Sphingomyelin phosphodiesterase 3 (SMPD3) is a protein from Homo sapiens identified by UniProt accession Q9NY59, 655 residues long. MolForge cross-references it against 0 known binders and 609 disease associations.
- UniProt accession: Q9NY59; gene symbol SMPD3.
- Organism: Homo sapiens.
- Length: 655 amino acids.
- Top disease associations (Open Targets): body height, Agouti-related protein measurement and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sphingomyelin phosphodiesterase 3 |
|---|---|
| UniProt accession | Q9NY59 |
| Gene | SMPD3 |
| Organism | Homo sapiens |
| Length | 655 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (609)
Diseases linked to this target (Open Targets).
- body height · score 0.34
- Agouti-related protein measurement · score 0.31
- erythrocyte count · score 0.30
- C-reactive protein measurement · score 0.26
- self reported educational attainment · score 0.26
- intelligence · score 0.25
- schizophrenia · score 0.25
- neurodegenerative disease · score 0.23
- sex hormone-binding globulin measurement · score 0.21
- body mass index · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NY59-F1 | alphafold | PREDICTED | 74.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NY59.
Amino-acid sequence (655 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMPD3?
The strongest Open Targets associations for SMPD3 are body height, Agouti-related protein measurement, erythrocyte count, C-reactive protein measurement and self reported educational attainment.
How long is the SMPD3 protein?
The Homo sapiens SMPD3 protein (UniProt Q9NY59) is 655 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NY59 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NY59 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.