Protein AATF (AATF)
Homo sapiens — UniProt Q9NY61
Data last refreshed: (UniProt release unknown)
Key facts
Protein AATF (AATF) is a protein from Homo sapiens identified by UniProt accession Q9NY61, 560 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q9NY61; gene symbol AATF.
- Organism: Homo sapiens.
- Length: 560 amino acids.
- Top disease associations (Open Targets): thyroid volume, physical activity and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein AATF |
|---|---|
| UniProt accession | Q9NY61 |
| Gene | AATF |
| Organism | Homo sapiens |
| Length | 560 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- thyroid volume · score 0.19
- physical activity · score 0.13
- high density lipoprotein cholesterol measurement · score 0.13
- macrophage inflammatory protein 1b measurement · score 0.12
- brain volume measurement · score 0.12
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.09
- attention deficit hyperactivity disorder · score 0.09
- cancer · score 0.08
- breast cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NY61-F1 | alphafold | PREDICTED | 64.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NY61.
Amino-acid sequence (560 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AATF?
The strongest Open Targets associations for AATF are thyroid volume, physical activity, high density lipoprotein cholesterol measurement, macrophage inflammatory protein 1b measurement and brain volume measurement.
How long is the AATF protein?
The Homo sapiens AATF protein (UniProt Q9NY61) is 560 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NY61 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NY61 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.