Tubulin alpha-8 chain (TUBA8)
Homo sapiens — UniProt Q9NY65
Data last refreshed: (UniProt release unknown)
Key facts
Tubulin alpha-8 chain (TUBA8) is a protein from Homo sapiens identified by UniProt accession Q9NY65, 449 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q9NY65; gene symbol TUBA8.
- Organism: Homo sapiens.
- Length: 449 amino acids.
- Top disease associations (Open Targets): macrothrombocytopenia, isolated, 2, autosomal dominant, polymicrogyria with optic nerve hypoplasia and viral disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tubulin alpha-8 chain |
|---|---|
| UniProt accession | Q9NY65 |
| Gene | TUBA8 |
| Organism | Homo sapiens |
| Length | 449 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.69
- polymicrogyria with optic nerve hypoplasia · score 0.58
- viral disease · score 0.46
- atrial fibrillation · score 0.39
- autosomal dominant macrothrombocytopenia · score 0.37
- lung adenocarcinoma · score 0.23
- endometrial cancer · score 0.23
- glioblastoma multiforme · score 0.23
- head and neck squamous cell carcinoma · score 0.23
- gastric adenocarcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NY65-F1 | alphafold | PREDICTED | 91.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NY65.
Amino-acid sequence (449 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TUBA8?
The strongest Open Targets associations for TUBA8 are macrothrombocytopenia, isolated, 2, autosomal dominant, polymicrogyria with optic nerve hypoplasia, viral disease, atrial fibrillation and autosomal dominant macrothrombocytopenia.
How long is the TUBA8 protein?
The Homo sapiens TUBA8 protein (UniProt Q9NY65) is 449 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NY65 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NY65 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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