Sodium channel regulatory subunit beta-3 (SCN3B)
Homo sapiens — UniProt Q9NY72
Data last refreshed: (UniProt release unknown)
Key facts
Sodium channel regulatory subunit beta-3 (SCN3B) is a protein from Homo sapiens identified by UniProt accession Q9NY72, 215 residues long. MolForge cross-references it against 6 known binders and 186 disease associations.
- UniProt accession: Q9NY72; gene symbol SCN3B.
- Organism: Homo sapiens.
- Length: 215 amino acids.
- Top disease associations (Open Targets): atrial fibrillation, familial atrial fibrillation and cardiac arrhythmia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sodium channel regulatory subunit beta-3 |
|---|---|
| UniProt accession | Q9NY72 |
| Gene | SCN3B |
| Organism | Homo sapiens |
| Length | 215 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (186)
Diseases linked to this target (Open Targets).
- atrial fibrillation · score 0.71
- familial atrial fibrillation · score 0.39
- cardiac arrhythmia · score 0.36
- Death in infancy · score 0.33
- breast adenocarcinoma · score 0.26
- Brugada syndrome · score 0.23
- glioblastoma multiforme · score 0.21
- Abnormality of the cardiovascular system · score 0.19
- gastric adenocarcinoma · score 0.15
- sudden cardiac arrest · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NY72-F1 | alphafold | PREDICTED | 86.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NY72.
Amino-acid sequence (215 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SCN3B?
The strongest Open Targets associations for SCN3B are atrial fibrillation, familial atrial fibrillation, cardiac arrhythmia, Death in infancy and breast adenocarcinoma.
How long is the SCN3B protein?
The Homo sapiens SCN3B protein (UniProt Q9NY72) is 215 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NY72 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NY72 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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