Sphingosine kinase 1 (SPHK1)
Homo sapiens — UniProt Q9NYA1
Data last refreshed: (UniProt release unknown)
Key facts
Sphingosine kinase 1 (SPHK1) is a protein from Homo sapiens identified by UniProt accession Q9NYA1, 384 residues long. MolForge cross-references it against 0 known binders and 438 disease associations.
- UniProt accession: Q9NYA1; gene symbol SPHK1.
- Organism: Homo sapiens.
- Length: 384 amino acids.
- Top disease associations (Open Targets): reticulocyte count, reticulocyte measurement and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sphingosine kinase 1 |
|---|---|
| UniProt accession | Q9NYA1 |
| Gene | SPHK1 |
| Organism | Homo sapiens |
| Length | 384 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (438)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.65
- reticulocyte measurement · score 0.65
- lymphocyte count · score 0.61
- Immature Reticulocyte Fraction Measurement · score 0.56
- neurodegenerative disease · score 0.33
- leukocyte count · score 0.32
- monocyte percentage of leukocytes · score 0.31
- ovarian cancer · score 0.25
- gastric adenocarcinoma · score 0.25
- endometrial cancer · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYA1-F1 | alphafold | PREDICTED | 91.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYA1.
Amino-acid sequence (384 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPHK1?
The strongest Open Targets associations for SPHK1 are reticulocyte count, reticulocyte measurement, lymphocyte count, Immature Reticulocyte Fraction Measurement and neurodegenerative disease.
How long is the SPHK1 protein?
The Homo sapiens SPHK1 protein (UniProt Q9NYA1) is 384 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYA1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYA1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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