Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (MTMR4)
Homo sapiens — UniProt Q9NYA4
Data last refreshed: (UniProt release unknown)
Key facts
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (MTMR4) is a protein from Homo sapiens identified by UniProt accession Q9NYA4, 1195 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9NYA4; gene symbol MTMR4.
- Organism: Homo sapiens.
- Length: 1195 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, glioblastoma multiforme and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 |
|---|---|
| UniProt accession | Q9NYA4 |
| Gene | MTMR4 |
| Organism | Homo sapiens |
| Length | 1195 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- glioblastoma multiforme · score 0.23
- breast adenocarcinoma · score 0.23
- HbA1c measurement · score 0.20
- body height · score 0.15
- head and neck squamous cell carcinoma · score 0.11
- refractive error · score 0.09
- age at first birth measurement · score 0.08
- granulocyte percentage of myeloid white cells · score 0.06
- intelligence · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYA4-F1 | alphafold | PREDICTED | 65.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYA4.
Amino-acid sequence (1195 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTMR4?
The strongest Open Targets associations for MTMR4 are neurodegenerative disease, glioblastoma multiforme, breast adenocarcinoma, HbA1c measurement and body height.
How long is the MTMR4 protein?
The Homo sapiens MTMR4 protein (UniProt Q9NYA4) is 1195 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYA4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYA4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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