Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP)
Homo sapiens — UniProt Q9NYB0
Data last refreshed: (UniProt release unknown)
Key facts
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) is a protein from Homo sapiens identified by UniProt accession Q9NYB0, 399 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.
- UniProt accession: Q9NYB0; gene symbol TERF2IP.
- Organism: Homo sapiens.
- Length: 399 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, glioblastoma multiforme and chronic lymphocytic leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Telomeric repeat-binding factor 2-interacting protein 1 |
|---|---|
| UniProt accession | Q9NYB0 |
| Gene | TERF2IP |
| Organism | Homo sapiens |
| Length | 399 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (109)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.27
- glioblastoma multiforme · score 0.23
- chronic lymphocytic leukemia · score 0.21
- gastric adenocarcinoma · score 0.21
- smoking status measurement · score 0.16
- genetic disorder · score 0.15
- prostate adenocarcinoma · score 0.14
- smoking behavior · score 0.11
- smoking initiation · score 0.11
- attention deficit hyperactivity disorder · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYB0-F1 | alphafold | PREDICTED | 72.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYB0.
Amino-acid sequence (399 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TERF2IP?
The strongest Open Targets associations for TERF2IP are breast adenocarcinoma, glioblastoma multiforme, chronic lymphocytic leukemia, gastric adenocarcinoma and smoking status measurement.
How long is the TERF2IP protein?
The Homo sapiens TERF2IP protein (UniProt Q9NYB0) is 399 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYB0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYB0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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