Abl interactor 2 (ABI2)
Homo sapiens — UniProt Q9NYB9
Data last refreshed: (UniProt release unknown)
Key facts
Abl interactor 2 (ABI2) is a protein from Homo sapiens identified by UniProt accession Q9NYB9, 513 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q9NYB9; gene symbol ABI2.
- Organism: Homo sapiens.
- Length: 513 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and thyroid gland adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Abl interactor 2 |
|---|---|
| UniProt accession | Q9NYB9 |
| Gene | ABI2 |
| Organism | Homo sapiens |
| Length | 513 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- breast adenocarcinoma · score 0.25
- thyroid gland adenocarcinoma · score 0.23
- white matter microstructure measurement · score 0.21
- glioblastoma multiforme · score 0.18
- multiple myeloma · score 0.13
- heel bone mineral density · score 0.11
- head and neck squamous cell carcinoma · score 0.11
- appendicular lean mass · score 0.10
- feeling "fed-up" measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYB9-F1 | alphafold | PREDICTED | 65.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYB9.
Amino-acid sequence (513 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ABI2?
The strongest Open Targets associations for ABI2 are neurodegenerative disease, breast adenocarcinoma, thyroid gland adenocarcinoma, white matter microstructure measurement and glioblastoma multiforme.
How long is the ABI2 protein?
The Homo sapiens ABI2 protein (UniProt Q9NYB9) is 513 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYB9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYB9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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