Dapper homolog 1 (DACT1)
Homo sapiens — UniProt Q9NYF0
Data last refreshed: (UniProt release unknown)
Key facts
Dapper homolog 1 (DACT1) is a protein from Homo sapiens identified by UniProt accession Q9NYF0, 836 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.
- UniProt accession: Q9NYF0; gene symbol DACT1.
- Organism: Homo sapiens.
- Length: 836 amino acids.
- Top disease associations (Open Targets): Townes-Brocks syndrome, neurodegenerative disease and colorectal cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dapper homolog 1 |
|---|---|
| UniProt accession | Q9NYF0 |
| Gene | DACT1 |
| Organism | Homo sapiens |
| Length | 836 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (172)
Diseases linked to this target (Open Targets).
- Townes-Brocks syndrome · score 0.60
- neurodegenerative disease · score 0.50
- colorectal cancer · score 0.39
- neuroimaging measurement · score 0.38
- cortical thickness · score 0.38
- spina bifida · score 0.37
- craniorachischisis · score 0.37
- occipital encephalocele · score 0.37
- colorectal adenoma · score 0.36
- cortical surface area measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYF0-F1 | alphafold | PREDICTED | 50.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYF0.
Amino-acid sequence (836 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DACT1?
The strongest Open Targets associations for DACT1 are Townes-Brocks syndrome, neurodegenerative disease, colorectal cancer, neuroimaging measurement and cortical thickness.
How long is the DACT1 protein?
The Homo sapiens DACT1 protein (UniProt Q9NYF0) is 836 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYF0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYF0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.