Bcl-2-associated transcription factor 1 (BCLAF1)
Homo sapiens — UniProt Q9NYF8
Data last refreshed: (UniProt release unknown)
Key facts
Bcl-2-associated transcription factor 1 (BCLAF1) is a protein from Homo sapiens identified by UniProt accession Q9NYF8, 920 residues long. MolForge cross-references it against 0 known binders and 232 disease associations.
- UniProt accession: Q9NYF8; gene symbol BCLAF1.
- Organism: Homo sapiens.
- Length: 920 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, acute myeloid leukemia and melanoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bcl-2-associated transcription factor 1 |
|---|---|
| UniProt accession | Q9NYF8 |
| Gene | BCLAF1 |
| Organism | Homo sapiens |
| Length | 920 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (232)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- acute myeloid leukemia · score 0.40
- melanoma · score 0.23
- hepatocellular carcinoma · score 0.21
- gastric adenocarcinoma · score 0.21
- esophageal squamous cell carcinoma · score 0.19
- non-small cell lung carcinoma · score 0.19
- chronic lymphocytic leukemia · score 0.19
- colon adenocarcinoma · score 0.19
- urinary bladder carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYF8-F1 | alphafold | PREDICTED | 46.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYF8.
Amino-acid sequence (920 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BCLAF1?
The strongest Open Targets associations for BCLAF1 are neurodegenerative disease, acute myeloid leukemia, melanoma, hepatocellular carcinoma and gastric adenocarcinoma.
How long is the BCLAF1 protein?
The Homo sapiens BCLAF1 protein (UniProt Q9NYF8) is 920 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYF8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYF8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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