Potassium channel subfamily K member 4 (KCNK4)
Homo sapiens — UniProt Q9NYG8
Data last refreshed: (UniProt release unknown)
Key facts
Potassium channel subfamily K member 4 (KCNK4) is a protein from Homo sapiens identified by UniProt accession Q9NYG8, 393 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q9NYG8; gene symbol KCNK4.
- Organism: Homo sapiens.
- Length: 393 amino acids.
- Top disease associations (Open Targets): facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome, gingival overgrowth and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Potassium channel subfamily K member 4 |
|---|---|
| UniProt accession | Q9NYG8 |
| Gene | KCNK4 |
| Organism | Homo sapiens |
| Length | 393 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome · score 0.64
- gingival overgrowth · score 0.52
- Intellectual disability · score 0.52
- Seizure · score 0.52
- Abnormal facial shape · score 0.43
- hypertrichosis · score 0.37
- Hypertrichosis · score 0.37
- Neurodevelopmental delay · score 0.37
- breast adenocarcinoma · score 0.22
- neutrophil count · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYG8-F1 | alphafold | PREDICTED | 78.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYG8.
Amino-acid sequence (393 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNK4?
The strongest Open Targets associations for KCNK4 are facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome, gingival overgrowth, Intellectual disability, Seizure and Abnormal facial shape.
How long is the KCNK4 protein?
The Homo sapiens KCNK4 protein (UniProt Q9NYG8) is 393 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYG8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYG8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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