Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4)
Homo sapiens — UniProt Q9NYJ1
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (COA4) is a protein from Homo sapiens identified by UniProt accession Q9NYJ1, 87 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q9NYJ1; gene symbol COA4.
- Organism: Homo sapiens.
- Length: 87 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, insomnia measurement and brain measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial |
|---|---|
| UniProt accession | Q9NYJ1 |
| Gene | COA4 |
| Organism | Homo sapiens |
| Length | 87 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- insomnia measurement · score 0.02
- brain measurement · score 0.02
- infection · score 0.02
- infect · score 0.02
- systemic juvenile idiopathic arthritis · score 0.01
- breast cancer · score 0.01
- influenza · score 0.01
- autoimmune myocarditis · score 0.01
- secondary progressive multiple sclerosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYJ1-F1 | alphafold | PREDICTED | 87.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYJ1.
Amino-acid sequence (87 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COA4?
The strongest Open Targets associations for COA4 are neurodegenerative disease, insomnia measurement, brain measurement, infection and infect.
How long is the COA4 protein?
The Homo sapiens COA4 protein (UniProt Q9NYJ1) is 87 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYJ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYJ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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