Delta-like protein 3 (DLL3)
Homo sapiens — UniProt Q9NYJ7
Data last refreshed: (UniProt release unknown)
Key facts
Delta-like protein 3 (DLL3) is a protein from Homo sapiens identified by UniProt accession Q9NYJ7, 618 residues long. MolForge cross-references it against 1 known binders and 175 disease associations.
- UniProt accession: Q9NYJ7; gene symbol DLL3.
- Organism: Homo sapiens.
- Length: 618 amino acids.
- Approved drugs acting on it (DrugCentral): Tarlatamab.
- Top disease associations (Open Targets): autosomal recessive spondylocostal dysostosis, neurodegenerative disease and small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Delta-like protein 3 |
|---|---|
| UniProt accession | Q9NYJ7 |
| Gene | DLL3 |
| Organism | Homo sapiens |
| Length | 618 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (175)
Diseases linked to this target (Open Targets).
- autosomal recessive spondylocostal dysostosis · score 0.72
- neurodegenerative disease · score 0.53
- small cell lung carcinoma · score 0.38
- leukodystrophy and acquired microcephaly with or without dystonia; · score 0.34
- Hemivertebrae · score 0.34
- Rib fusion · score 0.34
- syndactyly · score 0.19
- genetic disorder · score 0.19
- C-reactive protein measurement · score 0.15
- spondylocostal dysostosis · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYJ7-F1 | alphafold | PREDICTED | 65.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYJ7.
Amino-acid sequence (618 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target DLL3?
DrugCentral lists 1 approved drug whose mechanism of action is DLL3: Tarlatamab.
Which diseases are associated with DLL3?
The strongest Open Targets associations for DLL3 are autosomal recessive spondylocostal dysostosis, neurodegenerative disease, small cell lung carcinoma, leukodystrophy and acquired microcephaly with or without dystonia; and Hemivertebrae.
How long is the DLL3 protein?
The Homo sapiens DLL3 protein (UniProt Q9NYJ7) is 618 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYJ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYJ7 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.