TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2)
Homo sapiens — UniProt Q9NYJ8
Data last refreshed: (UniProt release unknown)
Key facts
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2) is a protein from Homo sapiens identified by UniProt accession Q9NYJ8, 693 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q9NYJ8; gene symbol TAB2.
- Organism: Homo sapiens.
- Length: 693 amino acids.
- Top disease associations (Open Targets): congenital heart malformation, genetic disorder and chromosome 6q24-q25 deletion syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 |
|---|---|
| UniProt accession | Q9NYJ8 |
| Gene | TAB2 |
| Organism | Homo sapiens |
| Length | 693 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- congenital heart malformation · score 0.75
- genetic disorder · score 0.47
- chromosome 6q24-q25 deletion syndrome · score 0.46
- neuroinflammatory disorder · score 0.39
- breast carcinoma · score 0.38
- COVID-19 · score 0.37
- neurodegenerative disease · score 0.36
- neutrophil percentage of leukocytes · score 0.35
- dilated cardiomyopathy · score 0.34
- Encephalopathy · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYJ8-F1 | alphafold | PREDICTED | 52.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYJ8.
Amino-acid sequence (693 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TAB2?
The strongest Open Targets associations for TAB2 are congenital heart malformation, genetic disorder, chromosome 6q24-q25 deletion syndrome, neuroinflammatory disorder and breast carcinoma.
How long is the TAB2 protein?
The Homo sapiens TAB2 protein (UniProt Q9NYJ8) is 693 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYJ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYJ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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