Toll-like receptor 7 (TLR7)
Homo sapiens — UniProt Q9NYK1
Data last refreshed: (UniProt release unknown)
Key facts
Toll-like receptor 7 (TLR7) is a protein from Homo sapiens identified by UniProt accession Q9NYK1, 1049 residues long. MolForge cross-references it against 2 known binders and 865 disease associations.
- UniProt accession: Q9NYK1; gene symbol TLR7.
- Organism: Homo sapiens.
- Length: 1049 amino acids.
- Approved drugs acting on it (DrugCentral): Hydroxychloroquine and Imiquimod.
- Top disease associations (Open Targets): systemic lupus erythematosus, COVID-19 and rheumatoid arthritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Toll-like receptor 7 |
|---|---|
| UniProt accession | Q9NYK1 |
| Gene | TLR7 |
| Organism | Homo sapiens |
| Length | 1049 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (865)
Diseases linked to this target (Open Targets).
- systemic lupus erythematosus · score 0.72
- COVID-19 · score 0.63
- rheumatoid arthritis · score 0.60
- actinic keratosis · score 0.59
- basal cell carcinoma · score 0.57
- malaria · score 0.57
- keratosis · score 0.55
- immunodeficiency 74, COVID-19-related, X-linked · score 0.55
- anogenital venereal wart · score 0.54
- IGA glomerulonephritis · score 0.54
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYK1-F1 | alphafold | PREDICTED | 87.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYK1.
Amino-acid sequence (1049 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target TLR7?
DrugCentral lists 2 approved drugs whose mechanism of action is TLR7: Hydroxychloroquine and Imiquimod.
Which diseases are associated with TLR7?
The strongest Open Targets associations for TLR7 are systemic lupus erythematosus, COVID-19, rheumatoid arthritis, actinic keratosis and basal cell carcinoma.
How long is the TLR7 protein?
The Homo sapiens TLR7 protein (UniProt Q9NYK1) is 1049 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYK1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYK1 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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