Large ribosomal subunit protein mL39 (MRPL39)
Homo sapiens — UniProt Q9NYK5
Data last refreshed: (UniProt release unknown)
Key facts
Large ribosomal subunit protein mL39 (MRPL39) is a protein from Homo sapiens identified by UniProt accession Q9NYK5, 338 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9NYK5; gene symbol MRPL39.
- Organism: Homo sapiens.
- Length: 338 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Leigh syndrome and mitochondrial disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large ribosomal subunit protein mL39 |
|---|---|
| UniProt accession | Q9NYK5 |
| Gene | MRPL39 |
| Organism | Homo sapiens |
| Length | 338 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- Leigh syndrome · score 0.36
- mitochondrial disease · score 0.31
- hair color · score 0.20
- hair colour measurement · score 0.14
- rheumatoid arthritis · score 0.14
- MODY · score 0.06
- neoplasm · score 0.06
- PHF-tau measurement · score 0.04
- Duane retraction syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYK5-F1 | alphafold | PREDICTED | 84.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYK5.
Amino-acid sequence (338 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRPL39?
The strongest Open Targets associations for MRPL39 are neurodegenerative disease, Leigh syndrome, mitochondrial disease, hair color and hair colour measurement.
How long is the MRPL39 protein?
The Homo sapiens MRPL39 protein (UniProt Q9NYK5) is 338 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYK5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYK5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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