Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)
Homo sapiens — UniProt Q9NYL2
Data last refreshed: (UniProt release unknown)
Key facts
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) is a protein from Homo sapiens identified by UniProt accession Q9NYL2, 800 residues long. MolForge cross-references it against 19 known binders and 179 disease associations.
- UniProt accession: Q9NYL2; gene symbol MAP3K20.
- Organism: Homo sapiens.
- Length: 800 amino acids.
- Top disease associations (Open Targets): myopathy, centronuclear, 6, with fiber-type disproportion, split-foot malformation-mesoaxial polydactyly syndrome and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitogen-activated protein kinase kinase kinase 20 |
|---|---|
| UniProt accession | Q9NYL2 |
| Gene | MAP3K20 |
| Organism | Homo sapiens |
| Length | 800 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (179)
Diseases linked to this target (Open Targets).
- myopathy, centronuclear, 6, with fiber-type disproportion · score 0.73
- split-foot malformation-mesoaxial polydactyly syndrome · score 0.72
- FEV/FVC ratio · score 0.42
- mathematical ability · score 0.40
- age at first sexual intercourse measurement · score 0.39
- diastolic blood pressure · score 0.38
- serum alanine aminotransferase measurement · score 0.37
- congenital fiber-type disproportion myopathy · score 0.37
- chronotype measurement · score 0.36
- high density lipoprotein cholesterol measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYL2-F1 | alphafold | PREDICTED | 68.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYL2.
Amino-acid sequence (800 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAP3K20?
The strongest Open Targets associations for MAP3K20 are myopathy, centronuclear, 6, with fiber-type disproportion, split-foot malformation-mesoaxial polydactyly syndrome, FEV/FVC ratio, mathematical ability and age at first sexual intercourse measurement.
How long is the MAP3K20 protein?
The Homo sapiens MAP3K20 protein (UniProt Q9NYL2) is 800 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYL2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYL2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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