24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1)
Homo sapiens — UniProt Q9NYL5
Data last refreshed: (UniProt release unknown)
Key facts
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1) is a protein from Homo sapiens identified by UniProt accession Q9NYL5, 469 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q9NYL5; gene symbol CYP39A1.
- Organism: Homo sapiens.
- Length: 469 amino acids.
- Top disease associations (Open Targets): sterol measurement, body height and urinary bladder cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 24-hydroxycholesterol 7-alpha-hydroxylase |
|---|---|
| UniProt accession | Q9NYL5 |
| Gene | CYP39A1 |
| Organism | Homo sapiens |
| Length | 469 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- sterol measurement · score 0.32
- body height · score 0.26
- urinary bladder cancer · score 0.11
- hepatocellular carcinoma · score 0.08
- lipoprotein-associated phospholipase A(2) measurement · score 0.07
- cerebrospinal fluid biomarker measurement · score 0.07
- neoplasm · score 0.07
- plasma fibronectin deficiency · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.06
- Hereditary persistence of alpha-fetoprotein · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYL5-F1 | alphafold | PREDICTED | 91.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYL5.
Amino-acid sequence (469 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYP39A1?
The strongest Open Targets associations for CYP39A1 are sterol measurement, body height, urinary bladder cancer, hepatocellular carcinoma and lipoprotein-associated phospholipase A(2) measurement.
How long is the CYP39A1 protein?
The Homo sapiens CYP39A1 protein (UniProt Q9NYL5) is 469 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYL5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYL5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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