Protein downstream neighbor of Son (DONSON)
Homo sapiens — UniProt Q9NYP3
Data last refreshed: (UniProt release unknown)
Key facts
Protein downstream neighbor of Son (DONSON) is a protein from Homo sapiens identified by UniProt accession Q9NYP3, 566 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q9NYP3; gene symbol DONSON.
- Organism: Homo sapiens.
- Length: 566 amino acids.
- Top disease associations (Open Targets): microcephaly, short stature, and limb abnormalities, microcephaly-micromelia syndrome and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein downstream neighbor of Son |
|---|---|
| UniProt accession | Q9NYP3 |
| Gene | DONSON |
| Organism | Homo sapiens |
| Length | 566 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- microcephaly, short stature, and limb abnormalities · score 0.77
- microcephaly-micromelia syndrome · score 0.70
- genetic disorder · score 0.52
- Meier-Gorlin syndrome · score 0.51
- Ear-patella-short stature syndrome · score 0.30
- Intellectual disability · score 0.27
- Short stature · score 0.27
- body height · score 0.16
- multiple congenital anomalies/dysmorphic syndrome-intellectual disability · score 0.11
- creatinine measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYP3-F1 | alphafold | PREDICTED | 72.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYP3.
Amino-acid sequence (566 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DONSON?
The strongest Open Targets associations for DONSON are microcephaly, short stature, and limb abnormalities, microcephaly-micromelia syndrome, genetic disorder, Meier-Gorlin syndrome and Ear-patella-short stature syndrome.
How long is the DONSON protein?
The Homo sapiens DONSON protein (UniProt Q9NYP3) is 566 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYP3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYP3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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