Retinol dehydrogenase 8 (RDH8)
Homo sapiens — UniProt Q9NYR8
Data last refreshed: (UniProt release unknown)
Key facts
Retinol dehydrogenase 8 (RDH8) is a protein from Homo sapiens identified by UniProt accession Q9NYR8, 311 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9NYR8; gene symbol RDH8.
- Organism: Homo sapiens.
- Length: 311 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lysosomal storage disease and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Retinol dehydrogenase 8 |
|---|---|
| UniProt accession | Q9NYR8 |
| Gene | RDH8 |
| Organism | Homo sapiens |
| Length | 311 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- lysosomal storage disease · score 0.29
- Parkinson disease · score 0.29
- Alzheimer disease · score 0.29
- multiple sclerosis · score 0.29
- ovarian cancer · score 0.18
- blood protein measurement · score 0.02
- atrial fibrillation · score 0.02
- breast carcinoma · score 0.01
- retinal degeneration · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYR8-F1 | alphafold | PREDICTED | 92.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYR8.
Amino-acid sequence (311 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RDH8?
The strongest Open Targets associations for RDH8 are neurodegenerative disease, lysosomal storage disease, Parkinson disease, Alzheimer disease and multiple sclerosis.
How long is the RDH8 protein?
The Homo sapiens RDH8 protein (UniProt Q9NYR8) is 311 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYR8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYR8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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