NF-kappa-B inhibitor-interacting Ras-like protein 2 (NKIRAS2)
Homo sapiens — UniProt Q9NYR9
Data last refreshed: (UniProt release unknown)
Key facts
NF-kappa-B inhibitor-interacting Ras-like protein 2 (NKIRAS2) is a protein from Homo sapiens identified by UniProt accession Q9NYR9, 191 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: Q9NYR9; gene symbol NKIRAS2.
- Organism: Homo sapiens.
- Length: 191 amino acids.
- Top disease associations (Open Targets): BMI-adjusted waist-hip ratio, osteosarcoma and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NF-kappa-B inhibitor-interacting Ras-like protein 2 |
|---|---|
| UniProt accession | Q9NYR9 |
| Gene | NKIRAS2 |
| Organism | Homo sapiens |
| Length | 191 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.04
- osteosarcoma · score 0.03
- neoplasm · score 0.02
- cancer · score 0.02
- glioblastoma multiforme · score 0.02
- glioblastoma · score 0.01
- non-small cell lung carcinoma · score 0.01
- urinary bladder carcinoma · score 0.01
- papilloma · score 0.01
- urothelial carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYR9-F1 | alphafold | PREDICTED | 89.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYR9.
Amino-acid sequence (191 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NKIRAS2?
The strongest Open Targets associations for NKIRAS2 are BMI-adjusted waist-hip ratio, osteosarcoma, neoplasm, cancer and glioblastoma multiforme.
How long is the NKIRAS2 protein?
The Homo sapiens NKIRAS2 protein (UniProt Q9NYR9) is 191 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYR9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYR9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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