NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1)
Homo sapiens — UniProt Q9NYS0
Data last refreshed: (UniProt release unknown)
Key facts
NF-kappa-B inhibitor-interacting Ras-like protein 1 (NKIRAS1) is a protein from Homo sapiens identified by UniProt accession Q9NYS0, 192 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q9NYS0; gene symbol NKIRAS1.
- Organism: Homo sapiens.
- Length: 192 amino acids.
- Top disease associations (Open Targets): Blackfan-Diamond anemia, intelligence and cognitive function measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
|---|---|
| UniProt accession | Q9NYS0 |
| Gene | NKIRAS1 |
| Organism | Homo sapiens |
| Length | 192 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- Blackfan-Diamond anemia · score 0.51
- intelligence · score 0.25
- cognitive function measurement · score 0.25
- mathematical ability · score 0.20
- self reported educational attainment · score 0.19
- verbal-numerical reasoning measurement · score 0.16
- appendicular lean mass · score 0.16
- body height · score 0.09
- testosterone measurement · score 0.08
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYS0-F1 | alphafold | PREDICTED | 87.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYS0.
Amino-acid sequence (192 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NKIRAS1?
The strongest Open Targets associations for NKIRAS1 are Blackfan-Diamond anemia, intelligence, cognitive function measurement, mathematical ability and self reported educational attainment.
How long is the NKIRAS1 protein?
The Homo sapiens NKIRAS1 protein (UniProt Q9NYS0) is 192 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYS0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYS0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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