Pleckstrin-2 (PLEK2)
Homo sapiens — UniProt Q9NYT0
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin-2 (PLEK2) is a protein from Homo sapiens identified by UniProt accession Q9NYT0, 353 residues long. MolForge cross-references it against 0 known binders and 173 disease associations.
- UniProt accession: Q9NYT0; gene symbol PLEK2.
- Organism: Homo sapiens.
- Length: 353 amino acids.
- Top disease associations (Open Targets): reticulocyte count, Immature Reticulocyte Fraction Measurement and reticulocyte measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin-2 |
|---|---|
| UniProt accession | Q9NYT0 |
| Gene | PLEK2 |
| Organism | Homo sapiens |
| Length | 353 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (173)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.26
- Immature Reticulocyte Fraction Measurement · score 0.22
- reticulocyte measurement · score 0.22
- head and neck squamous cell carcinoma · score 0.09
- lung adenocarcinoma · score 0.08
- esophageal squamous cell carcinoma · score 0.08
- neoplasm · score 0.08
- colorectal carcinoma · score 0.07
- cancer · score 0.07
- appendicular lean mass · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYT0-F1 | alphafold | PREDICTED | 85.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYT0.
Amino-acid sequence (353 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEK2?
The strongest Open Targets associations for PLEK2 are reticulocyte count, Immature Reticulocyte Fraction Measurement, reticulocyte measurement, head and neck squamous cell carcinoma and lung adenocarcinoma.
How long is the PLEK2 protein?
The Homo sapiens PLEK2 protein (UniProt Q9NYT0) is 353 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYT0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYT0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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