Cyclin-dependent kinase 12 (CDK12)
Homo sapiens — UniProt Q9NYV4
Data last refreshed: (UniProt release unknown)
Key facts
Cyclin-dependent kinase 12 (CDK12) is a protein from Homo sapiens identified by UniProt accession Q9NYV4, 1490 residues long. MolForge cross-references it against 2 known binders and 384 disease associations.
- UniProt accession: Q9NYV4; gene symbol CDK12.
- Organism: Homo sapiens.
- Length: 1490 amino acids.
- Top disease associations (Open Targets): prostate adenocarcinoma, neurodegenerative disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cyclin-dependent kinase 12 |
|---|---|
| UniProt accession | Q9NYV4 |
| Gene | CDK12 |
| Organism | Homo sapiens |
| Length | 1490 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (384)
Diseases linked to this target (Open Targets).
- prostate adenocarcinoma · score 0.66
- neurodegenerative disease · score 0.56
- lysosomal storage disease · score 0.50
- Alzheimer disease · score 0.50
- Parkinson disease · score 0.50
- multiple sclerosis · score 0.50
- ovarian epithelial tumor · score 0.38
- prostate carcinoma · score 0.37
- neuroinflammatory disorder · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYV4-F1 | alphafold | PREDICTED | 50.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYV4.
Amino-acid sequence (1490 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CDK12?
The strongest Open Targets associations for CDK12 are prostate adenocarcinoma, neurodegenerative disease, lysosomal storage disease, Alzheimer disease and Parkinson disease.
How long is the CDK12 protein?
The Homo sapiens CDK12 protein (UniProt Q9NYV4) is 1490 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYV4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYV4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.