RNA polymerase I-specific transcription initiation factor RRN3 (RRN3)
Homo sapiens — UniProt Q9NYV6
Data last refreshed: (UniProt release unknown)
Key facts
RNA polymerase I-specific transcription initiation factor RRN3 (RRN3) is a protein from Homo sapiens identified by UniProt accession Q9NYV6, 651 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9NYV6; gene symbol RRN3.
- Organism: Homo sapiens.
- Length: 651 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, colorectal adenocarcinoma and serum metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA polymerase I-specific transcription initiation factor RRN3 |
|---|---|
| UniProt accession | Q9NYV6 |
| Gene | RRN3 |
| Organism | Homo sapiens |
| Length | 651 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- colorectal adenocarcinoma · score 0.24
- serum metabolite measurement · score 0.15
- self reported educational attainment · score 0.13
- omega-6 polyunsaturated fatty acid measurement · score 0.13
- type 2 diabetes mellitus · score 0.12
- body mass index · score 0.12
- body weight · score 0.11
- lean body mass · score 0.11
- sex hormone-binding globulin measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYV6-F1 | alphafold | PREDICTED | 77.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYV6.
Amino-acid sequence (651 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RRN3?
The strongest Open Targets associations for RRN3 are neurodegenerative disease, colorectal adenocarcinoma, serum metabolite measurement, self reported educational attainment and omega-6 polyunsaturated fatty acid measurement.
How long is the RRN3 protein?
The Homo sapiens RRN3 protein (UniProt Q9NYV6) is 651 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYV6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYV6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.