Taste receptor type 2 member 14 (TAS2R14)
Homo sapiens — UniProt Q9NYV8
Data last refreshed: (UniProt release unknown)
Key facts
Taste receptor type 2 member 14 (TAS2R14) is a protein from Homo sapiens identified by UniProt accession Q9NYV8, 317 residues long. MolForge cross-references it against 2 known binders and 61 disease associations.
- UniProt accession: Q9NYV8; gene symbol TAS2R14.
- Organism: Homo sapiens.
- Length: 317 amino acids.
- Approved drugs acting on it (DrugCentral): Flufenamic Acid.
- Top disease associations (Open Targets): sensory perception of bitter taste, lung adenocarcinoma and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Taste receptor type 2 member 14 |
|---|---|
| UniProt accession | Q9NYV8 |
| Gene | TAS2R14 |
| Organism | Homo sapiens |
| Length | 317 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (61)
Diseases linked to this target (Open Targets).
- sensory perception of bitter taste · score 0.24
- lung adenocarcinoma · score 0.18
- breast adenocarcinoma · score 0.16
- blood protein measurement · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- coffee consumption · score 0.12
- tea consumption measurement · score 0.11
- attention deficit hyperactivity disorder · score 0.09
- coffee consumption measurement · score 0.08
- schizophrenia 15 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9NYV8-F1 | alphafold | PREDICTED | 81.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9NYV8.
Amino-acid sequence (317 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target TAS2R14?
DrugCentral lists 1 approved drug whose mechanism of action is TAS2R14: Flufenamic Acid.
Which diseases are associated with TAS2R14?
The strongest Open Targets associations for TAS2R14 are sensory perception of bitter taste, lung adenocarcinoma, breast adenocarcinoma, blood protein measurement and head and neck squamous cell carcinoma.
How long is the TAS2R14 protein?
The Homo sapiens TAS2R14 protein (UniProt Q9NYV8) is 317 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9NYV8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9NYV8 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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